▪ Abstract Naturally occurring CD4+ regulatory T cells, the majority of which express CD25,
are engaged in dominant control of self-reactive T cells, contributing to the maintenance of …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and
affect up to 15% of populations in Westernized countries. The description of Tregs as T cells …

Following activation by antigen, naive CD4+ T helper precursor cells execute distinct genetic
programs that result in their differentiation toward the type 1 or type 2 helper T cell (Th1 or …

The essential role played by CD25+ CD4+ regulatory T cells (TR cells) in the control of
physiological as well as pathological immunity is now well established, but many aspects of …

The Notch pathway is a widely utilized, evolutionarily conserved regulatory system that plays
a central role in the fate decisions of multipotent precursor cells. Notch often acts by …

Abstract CD25+ CD4+ Regulatory T cells (Treg) represent a unique population of
lymphocytes capable of powerfully suppressing immune responses. A large body of …

The Notch signaling pathway has become recognized as a vitally important pathway in
regulating proliferative/differentiative decisions and cell fate. To explore the involvement of …

On occasion, emerging scientific fields intersect and great discoveries result. In the last
decade, the discovery of regulatory T cells (Treg) in immunity has revolutionized our …

Thymic-derived dysregulated tolerance has been suggested to occur in type 1 diabetes via
impaired generation of CD4+ CD25+ T regulatory cells, leading to autoimmune β cell …