Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell
transcriptomics have revolutionized our understanding of cell composition and associated …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic
than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF …

Single-cell technology has allowed researchers to probe tissue complexity and dynamics at
unprecedented depth in health and disease. However, the generation of high-dimensionality …

The cardiac vascular and perivascular niche are of major importance in homeostasis and
during disease, but we lack a complete understanding of its cellular heterogeneity and …

Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction,.
However, the molecular mechanisms driving immune–fibroblast cell communication in …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal
mutations remains challenging. We hypothesized that genetic determinants for CHDs may …