Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …

Chemical surfactants are omnipresent in consumer products, but they are the subject of
environmental concerns. For this reason, the complete replacement of petrochemical …

This paper introduces ISOLDE, a new software package designed to provide an intuitive
environment for high-fidelity interactive remodelling/refinement of macromolecular models …

Although structures determined at near-atomic resolution are now routinely reported by cryo-
electron microscopy (cryo-EM), many density maps are determined at an intermediate …

We present a correlation-driven molecular dynamics (CDMD) method for automated
refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions …

Molecular simulations and biophysical experiments can be used to provide independent
and complementary insights into the molecular origin of biological processes. A particularly …

Recent advances in instrumentation and software have resulted in cryo-EM rapidly
becoming the method of choice for structural biologists, especially for those studying the …

We present a perspective of our view of the application of cryoelectron microscopy (cryo-EM)
to structure-based drug design (SBDD). We discuss the basic needs and requirements for …

Cryogenic electron microscopy (cryo-EM) has emerged as a powerful method for the
determination of structures of complex biological molecules. The accurate characterisation …

Single-particle cryogenic electron microscopy (cryo-EM) has revolutionized the field of the
structural biology, providing an access to the atomic resolution structures of large …