Epithelial–mesenchymal transitions (EMTs) are an important mechanism for reorganizing
germ layers and tissues during embryonic development. They have both a morphogenic …

Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture
that provides the basis for directional cell behavior. We find that planar polarity in the …

During convergent extension in Drosophila, polarized cell movements cause the germband
to narrow along the dorsal-ventral (DV) axis and more than double in length along the …

Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether
polarity loss might causally contribute to cancer has remained unclear. In Drosophila …

Summary Bazooka (PAR-3), PAR-6, and aPKC form a complex that plays a key role in the
polarization of many cell types. In epithelial cells, however, Bazooka localizes below PAR-6 …

Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced
tumors, cells invade the surrounding tissue and eventually form metastases. This is …

Epithelial cells use a striking array of morphogenetic behaviors to sculpt organs and body
plans during development. Although it is clear that epithelial morphogenesis is largely …

Intracellular protein transport is a key factor in epithelial cell polarity. Here we report that
mutations in two core components of the vesicle trafficking machinery—a syntaxin and a …

The development of human cancer is a multistep process, involving the cooperation of
mutations in signalling, cell-cycle and cell-death pathways, as well as interactions between …