Replication-coupled DNA repair
D Cortez - Molecular cell, 2019 - cell.com
The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …
However, it can make errors, especially when the template DNA is damaged. In these cases …
Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
A Bradbury, S Hall, N Curtin, Y Drew - Pharmacology & therapeutics, 2020 - Elsevier
The DNA damage response (DDR) machinery is responsible for detecting DNA damage,
pausing the cell cycle and initiating DNA repair. Ataxia telangiectasia and Rad3-related …
pausing the cell cycle and initiating DNA repair. Ataxia telangiectasia and Rad3-related …
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei
The human ataxia telangiectasia mutated and Rad3-related (ATR) kinase functions in the
nucleus to protect genomic integrity. Micronuclei (MN) arise from genomic and chromosomal …
nucleus to protect genomic integrity. Micronuclei (MN) arise from genomic and chromosomal …
ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition≠ deletion
DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates
a complex post-translational network termed DNA damage response (DDR). Our review …
a complex post-translational network termed DNA damage response (DDR). Our review …
TopBP1 assembles nuclear condensates to switch on ATR signaling
C Frattini, A Promonet, E Alghoul, S Vidal-Eychenie… - Molecular cell, 2021 - cell.com
ATR checkpoint signaling is crucial for cellular responses to DNA replication impediments.
Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self …
Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self …
[HTML][HTML] The hammer and the dance of cell cycle control
A Panagopoulos, M Altmeyer - Trends in biochemical sciences, 2021 - cell.com
Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
G Zonderland, R Vanzo, SA Gadi, E Martín-Doncel… - Molecular Cell, 2022 - cell.com
It has been proposed that ATR kinase senses the completion of DNA replication to initiate
the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex …
the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex …
An extending ATR–CHK1 circuitry: the replication stress response and beyond
A Simoneau, L Zou - Current opinion in genetics & development, 2021 - Elsevier
The maintenance of genomic integrity relies on the coordination of a wide range of cellular
processes and efficient repair of DNA damage. Since its discovery over two decades ago …
processes and efficient repair of DNA damage. Since its discovery over two decades ago …
Targeting replication stress response pathways to enhance genotoxic chemo-and radiotherapy
JA Nickoloff - Molecules, 2022 - mdpi.com
Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …
Emerging strategies for cancer therapy by ATR inhibitors
K Yano, B Shiotani - Cancer Science, 2023 - Wiley Online Library
DNA replication stress (RS) causes genomic instability and vulnerability in cancer cells. To
counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling …
counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling …