High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

PARP inhibitors have been proven clinically efficacious in platinum-responsive ovarian
cancer regardless of BRCA1/2 status and in breast cancers with germline BRCA1/2 …

Ovarian cancer is responsible for 4% of deaths from cancer in women. Treatment comprises
a combination of surgery and chemotherapy, but patients typically experience disease …

Mutations that drive uncontrolled cell-cycle progression are requisite events in
tumorigenesis. But evolution has installed in the proliferative programmes of mammalian …

Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …

Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known
about how the cancer initiates and metastasizes. In the last decade, new evidence has …

Interactions between tumour cells and the surrounding microenvironment contribute to
tumour progression, metastasis and recurrence,–. Although mosaic analyses in Drosophila …