Abstract Inositol 1, 4, 5-trisphosphate is a second messenger which regulates intracellular
calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by …

▪ Abstract The inositol 1, 4, 5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel
that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ …

RELEASE of calcium from intracellular stores occurs by two pathways, an inositol 1, 4, 5-
trisphosphate (InsP3)-gated channel1–3 and a calcium-gated channel (ryanodine receptor) …

The range of messenger action of a point source of Ca2+ or inositol 1, 4, 5-trisphosphate
(IP3) was determined from measurements of their diffusion coefficients in a cytosolic extract …

Ca2+ dependence of the inositol 1, 4, 5-trisphosphate (IP3)-induced Ca release was studied
in saponin-skinned smooth muscle fiber bundles of the guinea pig taenia caeci at 20-22 …

Inositol 1, 4, 5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …

The receptors for the second messenger inositol 1, 4, 5-trisphosphate (IP3) constitute a
family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three …

The immunosuppressant drug FK506 binds to the immunophilin protein FKBPl2 and inhibits
its prolyl isomeraseactivity. Immunosuppresiveactions, however, are mediated via an FK506 …

Kuriyama, H., K. Kitamura, T. Itoh, and R. Inoue. Physiological Features of Visceral Smooth
Muscle Cells, With Special Reference to Receptors and Ion Channels. Physiol. Rev. 78: 811 …

Inositol 1, 4, 5-trisphosphate (IP3) receptors are tetrameric intracellular Ca2+ channels, the
opening of which is regulated by both IP3 and Ca2+. We suggest that all IP3 receptors are …