Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …
which can be compared across CNS regions, patients, and centres. In patients with multiple …
Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …
with water between the wraps. The measurement of damage to the myelin sheaths, the …
The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation-A biochemical and histological validation study
S Hametner, V Endmayr, A Deistung, P Palmrich… - Neuroimage, 2018 - Elsevier
Quantitative susceptibility mapping (QSM) and effective transverse relaxation rate (R2*)
mapping are both highly sensitive to variations in brain iron content. Clinical Magnetic …
mapping are both highly sensitive to variations in brain iron content. Clinical Magnetic …
Myelin water imaging depends on white matter fiber orientation in the human brain
C Birkl, J Doucette, M Fan… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose The multi‐exponential T2 decay of the MRI signal from cerebral white matter can be
separated into short T2 components related to myelin water and long T2 components related …
separated into short T2 components related to myelin water and long T2 components related …
[HTML][HTML] Multiparameter MRI quantification of microstructural tissue alterations in multiple sclerosis
E Lommers, J Simon, G Reuter, G Delrue, D Dive… - NeuroImage: Clinical, 2019 - Elsevier
Objectives Conventional MRI is not sensitive to many pathological processes underpinning
multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI …
multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI …
Mechanisms of T2* anisotropy and gradient echo myelin water imaging
In MRI, structurally aligned molecular or micro‐organization (eg axonal fibers) can be a
source of substantial signal variations that depend on the structural orientation and the …
source of substantial signal variations that depend on the structural orientation and the …
[HTML][HTML] Orientation dependence of R2 relaxation in the newborn brain
In MRI the transverse relaxation rate, R 2= 1/T 2, shows dependence on the orientation of
ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R …
ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R …
Susceptibility‐sensitive MRI of multiple sclerosis lesions and the impact of normal‐appearing white matter changes
V Wiggermann, S Hametner… - NMR in …, 2017 - Wiley Online Library
Susceptibility‐sensitive magnetic resonance imaging (MRI) has gained importance in
multiple sclerosis (MS) research because of its versatility, high resolution and excellent …
multiple sclerosis (MS) research because of its versatility, high resolution and excellent …
Volumetric imaging of myelin in vivo using 3D inversion recovery‐prepared ultrashort echo time cones magnetic resonance imaging
Direct myelin imaging is promising for characterization of multiple sclerosis (MS) brains at
diagnosis and in response to therapy. In this study, a 3D inversion recovery‐prepared …
diagnosis and in response to therapy. In this study, a 3D inversion recovery‐prepared …
The role of iron and myelin in orientation dependent R2* of white matter
Brain myelin and iron content are important parameters in neurodegenerative diseases such
as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation …
as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation …