About 1.5 million new cases of cutaneous leishmaniasis and 500 000 new cases of visceral
leishmaniasis occur each year around the world. For over half a century, the clinical forms of …

The World Health Organization has classified the leishmaniasis as a major tropical disease.
An effective vaccine against leishmaniasis is not available and chemotherapy is the only …

Alkylphospholipids (APLs) represent a new class of drugs which do not interact directly with
DNA but act on the cell membrane where they accumulate and interfere with lipid …

Carajurin is the main constituent of Arrabidaea chica species with reported anti-Leishmania
activity. However, its mechanism of action has not been described. This study investigated …

Abstract According to the World Health Organization, leishmaniasis is considered as a major
neglected tropical disease causing an enormous impact on global public health. Available …

PURPOSE: Since when alkylphospholipds (ALPs) were discovered and, even further after
miltefosine's approval for the treatment of cutaneous metastasis of breast cancer and …

Neglected tropical diseases such as leishmaniasis and American trypanosomiasis represent
an increasing health problem. Current treatments are not satisfactory which remains an …

Miltefosine (hexadecylphosphocholine, MLF) is the first oral drug with recognized efficacy
against both visceral and cutaneous leishmaniasis. However, some clinical studies have …

Background The leishmaniases are a complex of neglected tropical diseases caused by
more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce …

Leishmaniasis is one of the neglected tropical diseases in terms of drug discovery and
development. Furthermore, the chemotherapy used to treat this disease has been proved to …