Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of
abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle …

Importance Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly
100 000 individuals in the United States and is associated with many acute and chronic …

Background and Purpose—This guideline provides an overview of the evidence on
established and emerging risk factors for stroke to provide evidence-based …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

One of every 600 black people in the United States has sickle cell anemia. In addition, sickle
cell–hemoglobin C disease and sickle cell–β-thalassemia, which are other common …

Vascular occlusion is the major cause of morbidity and mortality in sickle cell disease but its
mechanisms are poorly understood. We demonstrate by using intravital microscopy in mice …

A single amino acid substitution in hemoglobin comprises the molecular basis for sickle cell
anemia, but evolution of the corresponding clinical disease is extraordinarily complicated …

To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice
expressing human α-, γ-, and βS-globin were generated and bred with knockout mice that …

The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …

We used resequencing and genotyping in African Americans with sickle cell anemia (SCA)
to characterize associations with fetal hemoglobin (HbF) levels at the BCL11A, HBS1L-MYB …