Frontiers in CAR-T cell therapy for autoimmune diseases

YR Li, Z Lyu, Y Chen, Y Fang, L Yang - Trends in Pharmacological …, 2024 - cell.com
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has demonstrated
significant success in treating cancers. The potential of CAR-T cells is now being explored in …

Engineering strategies to safely drive CAR T-cells into the future

M Rossi, E Breman - Frontiers in Immunology, 2024 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer
treatment in the last decade, giving unprecedented results against hematological …

Incidentally cured psoriasis in a patient with refractory/relapsed diffuse large B-cell lymphoma receiving CD19 CAR-T cell therapy: a case report

S Wang, W An, Z Wang, W Wang, B Zhang… - Frontiers in …, 2024 - frontiersin.org
Chimeric antigen receptor T (CAR-T) cell therapy is a new treatment for cancers, but reports
on curing immune-related skin diseases are limited. We report a case of successful CAR-T …

Making the effect visible – OX40 targeting nanobodies for in vivo imaging of activated T cells

DI Frecot, S Blaess, TR Wagner, PD Kaiser… - Frontiers in …, 2024 - frontiersin.org
Purpose Human OX40 (hOX40/CD134), a member of the TNF receptor superfamily, is
mainly expressed on activated T lymphocytes. Triggered by its ligand OX40L (CD252), it …

The next frontier in multiple sclerosis therapies: Current advances and evolving targets.

KT Sastri, NV Gupta, A Kannan, S Dutta… - European Journal of …, 2024 - Elsevier
Recent advancements in research have significantly enhanced our comprehension of the
intricate immune components that contribute to multiple sclerosis (MS) pathogenesis. By …

Фармакотерапия аутоиммунных ревматических заболеваний–от моноклональных антител к CAR-T-клеткам: 20 лет спустя

ЕЛ Насонов, АГ Румянцев… - Научно-практическая …, 2024 - rsp.mediar-press.net
Аннотация Аутоиммунитет–патологический процесс, связанный с нарушением
иммунологической толерантности к нормальным структурным компонентам организма …

[HTML][HTML] Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions

GJ Adytia, H Sutanto, L Pratiwi, D Fetarayani - Immuno, 2025 - mdpi.com
Systemic autoimmune diseases (SAIDs) affect millions worldwide, presenting significant
clinical challenges due to their complex pathogenesis and limited treatment options …

Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment

L Chen, R Huang, C Huang, G Nong, Y Mo, L Ye… - Frontiers in …, 2025 - frontiersin.org
Cell therapy is an emerging strategy for precision treatment of scleroderma. This review
systematically summarizes the research progress of mesenchymal stem cell (MSC) and …

Strategies and delivery systems for cell-based therapy in autoimmunity

M Puccetti, C Costantini, A Schoubben… - Frontiers in Drug …, 2024 - frontiersin.org
This review article explores the potential of engineering antigen-presenting cells (APCs) for
the immunotherapy of autoimmune diseases. It discusses various strategies for modifying …

CD19 chimeric antigen receptor (CAR) T-cell therapy for systemic autoimmune diseases

AR Cingireddy, B Flores, J Wuthrich, AR Cingireddy - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
A small number of drugs have been the sole stay of conventional treatment for autoimmune
illnesses for the past 10 years. These medications have a number of side effects that restrict …