Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond

H Zhao, A Alam, AP Soo, AJT George, D Ma - EBioMedicine, 2018 - thelancet.com
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …

The clinical importance of nephron mass

VA Luyckx, BM Brenner - Journal of the American Society of …, 2010 - journals.lww.com
Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

Adult hypertension and kidney disease: the role of fetal programming

K Zandi-Nejad, VA Luyckx, BM Brenner - Hypertension, 2006 - Am Heart Assoc
Hypertension (HTN) and chronic kidney disease are highly prevalent diseases that tend to
occur more frequently among disadvantaged populations, in whom prenatal care also tends …

Clinical consequences of developmental programming of low nephron number

VA Luyckx, BM Brenner - The Anatomical Record, 2020 - Wiley Online Library
Nephron number in humans varies up to 13‐fold, likely reflecting the impact of multiple
factors on kidney development, including inherited body size and ethnicity, as well as …

[HTML][HTML] Donor kidney volume and outcomes following live donor kidney transplantation

ED Poggio, S Hila, B Stephany, R Fatica… - American journal of …, 2006 - Elsevier
Pre-donation kidney volume and function may be crucial factors in determining graft
outcomes in kidney transplant recipients. We measured living donor kidney volumes by 3D …

Kidney and recipient weight incompatibility reduces long-term graft survival

M Giral, Y Foucher, G Karam, Y Labrune… - Journal of the …, 2010 - journals.lww.com
Long-term function of kidney allografts depends on multiple variables, one of which may be
the compatibility in size between the graft and the recipient. Here, we assessed the long …

Preoperative assessment of the deceased-donor kidney: from macroscopic appearance to molecular biomarkers

AJ Dare, GJ Pettigrew, K Saeb-Parsy - Transplantation, 2014 - journals.lww.com
Variation in deceased-donor kidney quality can significantly affect outcomes after kidney
transplantation. Suboptimal organ selection for a given recipient can result in primary …

A comparative study of methods of estimating kidney length in kidney transplantation donors

KY Kang, YJ Lee, SC Park, CW Yang… - Nephrology Dialysis …, 2007 - academic.oup.com
Background. Knowledge of kidney size is important for clinical assessment of renal disease.
However, there are few studies on methods of assessing kidney size. The purpose of this …

[HTML][HTML] Low nephron number and its clinical consequences

VA Luyckx, K Shukha, BM Brenner - … Maimonides medical journal, 2011 - ncbi.nlm.nih.gov
Epidemiologic studies now strongly support the hypothesis, proposed over two decades
ago, that developmental programming of the kidney impacts an individual's risk for …

A kidney graft survival calculator that accounts for mismatches in age, sex, HLA, and body size

VB Ashby, AB Leichtman, MA Rees… - Clinical Journal of the …, 2017 - journals.lww.com
Results The dependence of graft failure on increasing donor age was less pronounced for
living-donor than for deceased-donor transplants. Male donor–to–male recipient transplants …