The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Anthrax is caused by the spore-forming, gram-positive bacterium Bacillus anthracis. The
bacterium's major virulence factors are (a) the anthrax toxins and (b) an antiphagocytic …

Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment
and activation of the pro‐inflammatory CASPASE‐1 protease. CASPASE‐1 activation leads …

The pathophysiological effects resulting from many bacterial diseases are caused by
exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a …

Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen
(PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA …

The limited efficacy of the current antitumor microenvironment strategies is due in part to the
poor understanding of the roles and relative contributions of the various tumor stromal cells …

Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-
positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the …

Multi-organ failure contributes to mortality in bacterial sepsis. Platelet and immune cell
activation contribute to organ injury during sepsis, but the mechanisms by which bacterial …

Bacterial products can act on neurons to alter signaling and function. In the present study,
we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the …