[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
The cardiovascular system: mathematical modelling, numerical algorithms and clinical applications
Mathematical and numerical modelling of the cardiovascular system is a research topic that
has attracted remarkable interest from the mathematical community because of its intrinsic …
has attracted remarkable interest from the mathematical community because of its intrinsic …
[HTML][HTML] A framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs
Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
E Passini, OJ Britton, HR Lu, J Rohrbacher… - Frontiers in …, 2017 - frontiersin.org
Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …
Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …
various cardiac diseases, which remain the most common cause of death in the developed …
A novel computational model of the human ventricular action potential and Ca transient
RESULTS. In 100 such simulated experiments we found a RMSD of 4.1451. 15 mV
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
Minimal model for human ventricular action potentials in tissue
Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …
stability require models that reproduce realistic characteristics in tissue. We present a …
[图书][B] Mathematical modelling of the human cardiovascular system: data, numerical approximation, clinical applications
Mathematical and numerical modelling of the human cardiovascular system has attracted
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
S Dutta, KC Chang, KA Beattie, J Sheng… - Frontiers in …, 2017 - frontiersin.org
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …
drugs from the market and is therefore of major concern to global regulatory agencies and …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …