Cryptotanshinone: A review of its pharmacology activities and molecular mechanisms

YH Wu, YR Wu, B Li, ZY Yan - Fitoterapia, 2020 - Elsevier
As a natural quinone compound, the medicinal value of cryptotanshinone (CT) has received
increasing attentions, but there is no systematic literature review that describes the …

Recent insights into the biological activities and drug delivery systems of tanshinones

Y Cai, W Zhang, Z Chen, Z Shi, C He… - International Journal of …, 2016 - Taylor & Francis
Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal
herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the …

[HTML][HTML] Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

S Raimondo, F Naselli, S Fontana, F Monteleone… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Nanosized vesicles are considered key players in cell to cell communication, thus
influencing physiological and pathological processes, including cancer. Nanovesicles have …

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

HH Cao, JH Chu, HY Kwan, T Su, H Yu, CY Cheng… - Scientific reports, 2016 - nature.com
Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in
human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a …

[HTML][HTML] Cryptotanshinone inhibites bladder cancer cell proliferation and promotes apoptosis via the PTEN/PI3K/AKT pathway

Y Liu, F Lin, Y Chen, R Wang, J Liu, Y Jin… - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Cryptotanshinone (CTT), extracted from the root of Salvia miltiorrhiza Bunge (Danshen),
exhibits activities against a variety of human cancers in vitro and in vivo. The purpose of this …

Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion

T Ye, S Zhu, Y Zhu, Q Feng, B He, Y Xiong… - Biomedicine & …, 2016 - Elsevier
Melanoma is the most serious type of skin cancer because it is highly frequency of drug
resistance and can spread earlier and more quickly than other skin cancers. The objective of …

Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge

YC Hung, TL Pan, WL Hu - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Cancer is a leading cause of death worldwide. We aim to provide a systematic review about
the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza …

Targeting death receptors for TRAIL by agents designed by Mother Nature

S Prasad, JH Kim, SC Gupta, BB Aggarwal - Trends in pharmacological …, 2014 - cell.com
Selective killing of cancer cells is one of the major goals of cancer therapy. Although
chemotherapeutic agents are being used for cancer treatment, they lack selectivity toward …

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

M Ashrafizadeh, A Zarrabi, S Orouei… - Phytotherapy …, 2021 - Wiley Online Library
In respect to the enhanced incidence rate of cancer worldwide, studies have focused on
cancer therapy using novel strategies. Chemotherapy is a common strategy in cancer …

[HTML][HTML] Stimulation of eryptosis by cryptotanshinone

R Bissinger, A Lupescu, C Zelenak, K Jilani… - Cellular Physiology and …, 2014 - karger.com
Background/Aims: Cryptotanshinone, a component of Salvia miltiorrhiza Bunge roots, may
trigger suicidal death or apoptosis of tumor cells and has thus been recommended for the …