The human cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI) anchored
membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. This protein …

An almost unique place within protein databases, twenty-five years of study has
underscored the enigmatically subtle role of PrP C in normal cell biology. It seems that PrP …

The prion protein PrP has a key role in transmissible spongiform encephalopathies but its
biological function remains largely unknown. Recently, a related protein, Shadoo, was …

Prion diseases in sheep and goats are called scrapie and belong to a group of transmissible
spongiform encephalopathies (TSEs) caused by the abnormal misfolding of the prion protein …

Using comparative genomics and in-silico analyses, we previously identified a new member
of the prion-protein (PrP) family, the gene SPRN, encoding the protein Shadoo (Sho), and …

Prion diseases are fatal neurodegenerative diseases of humans and animals which, in
addition to sporadic and familial modes of manifestation, can be acquired via an infectious …

Bovine spongiform encephalopathy (BSE) is a prion disease that is invariably fatal in cattle
and has been implicated as a significant human health risk. As a transmissible disease of …

[Frontiers in Bioscience 16, 1505-1516, January 1, 2011] 1505 Biological properties of the
PrP-like Shadoo protein Nathalie Daud Page 1 [Frontiers in Bioscience 16, 1505-1516, January …

Polymorphisms in the coding region of the prion protein gene (PRNP) have been associated
with the susceptibility and incubation period of prion diseases in humans and sheep …

Prion diseases in ruminants, especially sheep scrapie, cannot be fully explained by PRNP
genetics, suggesting the influence of a second modulator gene. The SPRN gene is a good …