Patterns of variation and evolution at a given site in a genome can be strongly influenced by
the effects of selection at genetically linked sites. In particular, the recombination rates of …

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

The genetic composition of the gut microbiota is constantly reshaped by ecological and
evolutionary forces. These strain-level dynamics are challenging to understand because …

Cultivated strawberry (Fragaria× ananassa) is one of our youngest domesticates, originating
in early eighteenth-century Europe from spontaneous hybrids between wild allo-octoploid …

Abstract Background The genus Zingiber of the Zingiberaceae is distributed in tropical,
subtropical, and in Far East Asia. This genus contains about 100–150 species, with many …

As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …

Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an
immune response, and consequently undergo evolutionary selection. Here we establish …

Highly fecund natural populations characterized by high early mortality abound, yet our
knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap …