4-methylpyrazole protects against acetaminophen-induced acute kidney injury

JY Akakpo, A Ramachandran, H Orhan… - Toxicology and applied …, 2020 - Elsevier
Acetaminophen (APAP) hepatotoxicity is the most common cause of acute liver failure in the
United States, and while a significant percentage of APAP overdose patients develop kidney …

[HTML][HTML] Renoprotective effects of cinnamon oil against APAP-Induced nephrotoxicity by ameliorating oxidative stress, apoptosis and inflammation in rats

S Alshahrani, M Ashafaq, S Hussain… - Saudi Pharmaceutical …, 2021 - Elsevier
Acetaminophen (APAP) is used as a primary medication in relieving moderate pain and
fever. However, APAP is associated with toxic effects in renal tissue that appear because of …

Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats

ZA Zakaria, FH Kamisan, TL Kek… - Pharmaceutical …, 2020 - Taylor & Francis
Abstract Context Dicranopteris linearis L.(Gleicheniaceae) leaves have been reported to
exert hepatoprotective activity. Objective The hepatoprotective and antioxidant effects of …

Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging

JY Akakpo, H Olivos, B Shrestha, A Midey… - Toxicological …, 2024 - academic.oup.com
Acute kidney injury (AKI) is a common complication in acetaminophen (APAP) overdose
patients and can negatively impact prognosis. Unfortunately, N-acetylcysteine, which is the …

Caesalpinia bonducella mitigates oxidative damage by paracetamol intoxication in the kidney and intestine via modulating pro/anti-inflammatory and apoptotic …

S Nithiyanandam, S Evan Prince - 3 Biotech, 2023 - Springer
Protracted use of paracetamol at therapeutic/toxic doses readily induces major organ toxicity
and poor clinical efficacy. Caesalpinia bonducella seeds possess a diverse range of …

Safe and appropriate use of diclofenac in chronic kidney disease: An Indian perspective

S Sheth, S Thakur, A Thorat… - Journal of Family Medicine …, 2021 - journals.lww.com
Pain is most common symptom associated with progressive disorder, chronic kidney
disease (CKD), and is usually undertreated during the early stages of CKD. So, present …

Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice

X Zhang, F Long, R Li, Y Yang, T Wang… - Environmental …, 2022 - Wiley Online Library
It's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the
present study, we investigated the preventative effect of Tan IIA on APAP‐induced …

[HTML][HTML] Hepatoprotective effect of β-myrcene pretreatment against acetaminophen-induced liver injury

GFE Cardia, FM de Souza Silva-Comar… - Avicenna Journal of …, 2022 - ncbi.nlm.nih.gov
Objective: In the present study, the hepatoprotective effects of β-myrcene (MYR) on
acetaminophen-induced hepatotoxicity were investigated. Materials and Methods: A total of …

Ulva fasciata, a green alga, attenuates the kidney and liver dysfunctions in rats induced by acetaminophen

N Sohail, M Azam, H Farhat, K Hira… - Drug and Chemical …, 2024 - Taylor & Francis
Acetaminophen (AAP) is an analgesic–antipyretic drug which is considered safe at
recommended dose, but its overuse may induce renal and hepatic injuries. Marine macro …

[HTML][HTML] Acute renal impairment in patients due to paracetamol overdose in the absence of hepatic impairment

Z Khan, M Abumedian, M Ibekwe, K Musa, G Mlawa - Cureus, 2021 - ncbi.nlm.nih.gov
In general, paracetamol poisoning is associated with hepatotoxicity and very rarely with
renal impairment in the absence of significant hepatic impairment. Paracetamol poisoning …