Recent advances in the modeling of Alzheimer's disease
H Sasaguri, S Hashimoto, N Watamura… - Frontiers in …, 2022 - frontiersin.org
Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …
[HTML][HTML] Adult hippocampal neurogenesis and its impairment in Alzheimer's disease
TA Kim, MD Syty, K Wu, S Ge - Zoological research, 2022 - ncbi.nlm.nih.gov
Adult neurogenesis is the creation of new neurons which integrate into the existing neural
circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis …
circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis …
Mouse models of Alzheimer's disease for preclinical research
N Watamura, K Sato, TC Saido - Neurochemistry International, 2022 - Elsevier
Most mouse models for preclinical research into Alzheimer's disease (AD) rely on the
overexpression paradigm, in which familial AD (FAD)-related genes linked to amyloid …
overexpression paradigm, in which familial AD (FAD)-related genes linked to amyloid …
Myeloid arginase 1 insufficiency exacerbates amyloid-β associated neurodegenerative pathways and glial signatures in a mouse model of Alzheimer's disease: a …
Brain myeloid cells, include infiltrating macrophages and resident microglia, play an
essential role in responding to and inducing neurodegenerative diseases, such as …
essential role in responding to and inducing neurodegenerative diseases, such as …
Critical thinking of Alzheimer's transgenic mouse model: current research and future perspective
X Li, M Quan, Y Wei, W Wang, L Xu, Q Wang… - Science China Life …, 2023 - Springer
Transgenic models are useful tools for studying the pathogenesis of and drug development
for Alzheimer's Disease (AD). AD models are constructed usually using overexpression or …
for Alzheimer's Disease (AD). AD models are constructed usually using overexpression or …
Temporal and spatially controlled APP transgene expression using Cre-dependent alleles
Although a large number of mouse models have been made to study Alzheimer's disease,
only a handful allow experimental control over the location or timing of the protein being …
only a handful allow experimental control over the location or timing of the protein being …
Improving mouse models for the study of Alzheimer's disease
AM Reagan, KD Onos, SE Heuer, M Sasner… - Current topics in …, 2022 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease whose risk is influenced
by genetic and environmental factors. Although a number of pathological hallmarks have …
by genetic and environmental factors. Although a number of pathological hallmarks have …
Improving mouse models for the study of Alzheimer's
AM Reagana, KD Onosa, SE Heuera… - Mouse Models of …, 2022 - books.google.com
3.1 Accelerating medicines partnerships: AlzheimerLs disease 3.2 Model organism
development and evaluation for late onset AlzheimerLs disease (MODEL-AD) 4. Modeling …
development and evaluation for late onset AlzheimerLs disease (MODEL-AD) 4. Modeling …