Cellular responses to stress can be defined by the overwhelming number of changes that
cells go through upon contact with and stressful conditions such as infection and …

Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

Within the human host, Legionella pneumophila replicates within alveolar macrophages,
leading to pneumonia. However, L. pneumophila is an aquatic generalist pathogen that …

Legionella pneumophila (L. pneumophila) is a gram-negative bacterium that replicates in a
compartment that resembles the host endoplasmic reticulum (ER). To create its replicative …

Protein ubiquitination is a posttranslational modification that regulates many aspects of
cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-κB activation. By …

Legionella pneumophila is a gram‐negative bacteria found in natural and anthropogenic
aquatic environments such as evaporative cooling towers, where it reproduces as an …

The intracellular bacterial pathogen Legionella pneumophila uses many effector proteins
delivered by the bacterial type IV secretion system (T4SS) to hijack the early secretory …

Autophagy and apoptosis are two recognized mechanisms of resistance to bacterial
invasion. However, bacteria have likewise evolved the ability to evade immunity. In this …

Autophagy is an evolutionary conserved catabolic process that allows for the degradation of
intracellular components by lysosomes. This process can be triggered by nutrient …