Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol
and the risk of coronary heart disease, the protection of susceptible animals from …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Apoptotic cell death following injury of vascular endothelium is assumed to play an important
role in the pathogenesis of atherosclerosis. In this report, we demonstrate that high density …

Tangier disease is an autosomal recessive genetic disorder characterized by a severe high-
density lipoprotein (HDL) deficiency, sterol deposition in tissue macrophages, and prevalent …

Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active
transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly …

It is widely believed that high density lipoprotein (HDL) protects against cardiovascular
disease by removing excess cholesterol from cells of the artery wall. Recent cell culture …

Caveolae are free cholesterol (FC)-and sphingolipid-rich surface microdomains abundant in
most peripheral cells. Caveolin, a FC binding protein, is a major structural element of these …

Several HDL binding proteins, quite disparate in structure, have recently been cloned and
their role in HDL metabolism is currently being assessed. High density lipoprotein binding …