Cerebellar reserve refers to the capacity of the cerebellum to compensate for tissue damage
or loss of function resulting from many different etiologies. When the inciting event produces …

Glutamic acid decarboxylase (GAD) is an intracellular enzyme whose physiologic function is
the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the main inhibitory …

Background Cerebellar ataxias are the result of diverse disease processes that can be
genetic or acquired. Establishing a diagnosis requires a methodical approach with expert …

Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic in
December 2019, neurological manifestations have been recognized as potential …

Aside from well-characterized immune-mediated ataxias with a clear trigger and/or
association with specific neuronal antibodies, a large number of idiopathic ataxias are …

Movement disorders (MDs) are common in patients with autoimmune disorders affecting the
central and peripheral nervous system. They may be observed in autoimmune disorders …

Immune-mediated cerebellar ataxias (IMCAs), a clinical entity reported for the first time in the
1980s, include gluten ataxia (GA), paraneoplastic cerebellar degenerations (PCDs) …

Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar
degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto's …

Purpose of review: To provide an update on paraneoplastic cerebellar degeneration (PCD),
the involved antibodies and tumors, as well as management strategies. Recent findings …