The revival of aztreonam in combination with avibactam against metallo-β-lactamase-producing Gram-negatives: a systematic review of in vitro studies and clinical …
Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and
Pseudomonas are increasingly reported worldwide and are usually associated with high …
Pseudomonas are increasingly reported worldwide and are usually associated with high …
Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in Enterobacteriaceae
G De Angelis, P Del Giacomo, B Posteraro… - International journal of …, 2020 - mdpi.com
Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …
severe infections such as bloodstream infections. The β-lactam drugs have been the …
Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes
It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
Critical importance of a one health approach to antimicrobial resistance
A White, JM Hughes - EcoHealth, 2019 - Springer
Antimicrobial resistance (AMR) is a complex, multifaceted problem that threatens human
and animal health, the global economy, and national and global security. In the USA, an …
and animal health, the global economy, and national and global security. In the USA, an …
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas …
JC Hamrick, JD Docquier, T Uehara… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
As shifts in the epidemiology of β-lactamase-mediated resistance continue, carbapenem-
resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa …
resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa …
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace
Acinetobacter baumannii is a common cause of serious nosocomial infections. Although
community-acquired infections are observed, the vast majority occur in people with …
community-acquired infections are observed, the vast majority occur in people with …
An update on β-lactamase inhibitor discovery and development
JD Docquier, S Mangani - Drug Resistance Updates, 2018 - Elsevier
Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …
threatens our capability to treat bacterial diseases, including potentially deadly hospital …
Drivers of antibiotic resistance transmission in low-and middle-income countries from a “one health” perspective—a review
Antibiotic resistance is an ecosystem problem threatening the interrelated human-animal-
environment health under the “One Health” framework. Resistant bacteria arising in one …
environment health under the “One Health” framework. Resistant bacteria arising in one …
Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems
Soils in tropical and temperate locations are known to be a sink for the genetic potential of
anthropogenic-driven acquired antibiotic resistance (AR). In contrast, accumulation of …
anthropogenic-driven acquired antibiotic resistance (AR). In contrast, accumulation of …
The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase
BO Ma, C Fang, L Lu, M Wang, X Xue, Y Zhou… - Nature …, 2019 - nature.com
New Delhi metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase
and hydrolyzes almost all clinically used β-lactam antibiotics. Here we show that the …
and hydrolyzes almost all clinically used β-lactam antibiotics. Here we show that the …