Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …

The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental
signals from growth factors and nutrients to metabolic networks and adaptive cellular …

Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), the mammalian ortholog of
yeast vesicular protein sorting 34 (Vps34), belongs to the phosphoinositide 3-kinase (PI3K) …

In autophagy, LC3‐positive autophagophores fuse and encapsulate the autophagic cargo in
a double‐membrane structure. In contrast, lipidated LC3 (LC3‐II) is directly formed at the …

Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune-driven connective
tissue disorder that results in fibrosis of the skin and internal organs such as the lung …

Autophagy is an intracellular process that targets various cargos for degradation, including
members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double …

The distinct movements of macropinosome formation and maturation have corresponding
biochemical activities which occur in a defined sequence of stages and transitions between …

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by
germline mutations in TSC1 or TSC2 genes, which leads to the hyperactivation of the …

Lymphangioleiomyomatosis is a rare destructive lung disease affecting primarily women
and is the primary lung manifestation of tuberous sclerosis complex (TSC). In …