Experimental research during the past decade has greatly increased our understanding of
the pathophysiology of traumatic brain injury (TBI) and allowed us to develop …

Stroke remains a major brain disorder that often renders patients severely impaired and
permanently disabled. There is no available treatment for reversing these deficits …

The role of glial cells in neuronal death has become a major research interest. Glial cell
activation has been demonstrated to accompany cerebral ischemia. However, there is …

We investigated the effects of a potent antioxidant, lycopene, on the free radical-scavenging
activity as evaluated by the DPPH test and lipid peroxidation in rat brain homogenates as …

Microhemorrhages are common in the aging brain, and their incidence is correlated with
increased risk of neurodegenerative disease. Past work has shown that occlusion of …

Aim: To examine the detailed mechanisms underlying the inhibitory effect of
tetramethylpyrazine (TMPZ) in inflammatory and apoptotic responses induced by middle …

Background Delta opioid peptide [D-ala2, D-leU5] enkephalin (DADLE) induces hibernation
in summer ground squirrels, and enhances preservation and survival of isolated or …

Reduction of cerebral edema, an early symptom of ischemia, is one of the most important
remedies for reducing subsequent chronic neural damage in stroke. Melatonin, a metabolite …

Objective—Inosine is a naturally occurring nucleoside degraded from adenosine. Recent
studies have demonstrated that inosine has potent immunomodulatory and neuroprotective …

Focal epilepsies are often associated with blood-brain barrier disruption. In 4 entorhinal
cortex tissue samples and 13 hippocampal samples from patients with pharmacoresistent …