Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Bone grafts are the second most common tissue transplanted in the United States, and they
are an essential treatment tool in the field of acute and reconstructive traumatic orthopaedic …

Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …

There is a significant burden of disease associated with bone defects, and their
management is challenging. These injuries have a profound clinical and economic impact …

The identification and production of recombinant morphogens and growth factors that play
key roles in tissue regeneration have generated much enthusiasm and numerous clinical …

Medical advances have led to a welcome increase in life expectancy. However,
accompanying longevity introduces new challenges: increases in age-related diseases and …

Objective To evaluate the impact of non-blinded outcome assessment on estimated
treatment effects in randomised clinical trials with binary outcomes. Design Systematic …

Regeneration of bone and cartilage defects can be accelerated by localized delivery of
appropriate growth factors incorporated within biodegradable carriers. The carrier …

The combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an
absorbable collagen sponge (ACS) carrier has been shown to induce bone formation in a …