Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Viral replication is rapid and robust, but it is far from a chaotic process. Instead, successful
production of infectious progeny requires that events occur in the correct place and at the …

Rotavirus assembly is a complex process that involves the stepwise acquisition of protein
layers in distinct intracellular locations to form the fully assembled particle. Understanding …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

The rotavirus (RV) genome comprises 11 segments of double-stranded RNA (dsRNA) and is
contained within a non-enveloped, icosahedral particle. During assembly, a highly …

The morphogenesis of rotaviruses follows a unique pathway in which immature double-
layered particles (DLPs) assembled in the cytoplasm bud across the membrane of the …

Early during the infection process, rotavirus causes the shutoff of cell protein synthesis, with
the nonstructural viral protein NSP3 playing a vital role in the phenomenon. In this work, we …

The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses
with genomes consisting of 11 segments of double-stranded (ds) RNA. A characteristic …

ROTAVIRUS NONSTRUCTURAL PROTEIN 4 (NSP4) en-coded by gene 10 is the first
described viral enterotoxin (7). Since the report of the NSP4 toxic activity, identification of …

Rotavirus is a major cause of infantile viral gastroenteritis. Rotavirus nonstructural protein 4
(NSP4) has pleiotropic properties and functions in viral morphogenesis as well as …