Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in
air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by
episodically exuberant heterotopic ossification (HO), whereby skeletal muscle is abnormally …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by
extraskeletal bone formation through endochondral ossification. FOP patients harbor point …

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder
characterized by progressive and profoundly disabling heterotopic ossification (HO). Here …

Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO)
syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I …

Fibrodysplasia ossificans progressiva (FOP), a rare and as yet untreatable genetic disorder
of progressive extraskeletal ossification, is the most disabling form of heterotopic ossification …

Heterotopic ossification (HO) is a clinical condition that often reduces mobility and
diminishes quality of life for affected individuals. The most severe form of progressive HO …

Hypoxia and inflammation are implicated in the episodic induction of heterotopic
endochondral ossification (HEO); however, the molecular mechanisms are unknown. HIF …

Bone development is a tightly regulated process. Several integrated signaling pathways
including HH, PTHrP, WNT, NOTCH, TGF-β, BMP, FGF and the transcription factors SOX9 …