[HTML][HTML] Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma

J Lv, L Guo, JJ Liu, HP Zhao, J Zhang… - World journal of …, 2019 - ncbi.nlm.nih.gov
The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Pharmacological induction of fetal hemoglobin in β-thalassemia and sickle cell disease: An updated perspective

R Bou-Fakhredin, L De Franceschi, I Motta… - Pharmaceuticals, 2022 - mdpi.com
A significant amount of attention has recently been devoted to the mechanisms involved in
hemoglobin (Hb) switching, as it has previously been established that the induction of fetal …

CD5 deletion enhances the antitumor activity of adoptive T cell therapies

RP Patel, G Ghilardi, Y Zhang, YH Chiang, W Xie… - Science …, 2024 - science.org
Most patients treated with US Food and Drug Administration (FDA)–approved chimeric
antigen receptor (CAR) T cells eventually experience disease progression. Furthermore …

Worldwide CRISPR patent landscape shows strong geographical biases

J Martin-Laffon, M Kuntz, AE Ricroch - Nature Biotechnology, 2019 - nature.com
Worldwide CRISPR patent landscape shows strong geographical biases | Nature Biotechnology
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

[PDF][PDF] Patient data ownership: who owns your health?

K Liddell, DA Simon, A Lucassen - Journal of Law and the …, 2021 - academic.oup.com
This article answers two questions from the perspective of United Kingdom law and policy:(i)
is health information property? and (ii) should it be? We argue that special features of health …

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production

C Zuccato, LC Cosenza, M Zurlo, I Lampronti… - International Journal of …, 2021 - mdpi.com
β-thalassemias are among the most common inherited hemoglobinopathies worldwide and
are the result of autosomal mutations in the gene encoding β-globin, causing an absence or …

CRISPR in public health: the health equity implications and role of community in gene-editing research and applications

AM Subica - American Journal of Public Health, 2023 - ajph.aphapublications.org
CRISPR (clustered regularly interspaced short palindromic repeats) is a Nobel Prize–
winning technology that holds significant promise for revolutionizing the prevention and …

[HTML][HTML] Market access of gene therapies across Europe, USA, and Canada: challenges, trends, and solutions

E van Overbeeke, S Michelsen, M Toumi, H Stevens… - Drug discovery today, 2021 - Elsevier
Highlights•Challenges blocking market access of GTMPs are highly interrelated.•Developers
should seek support and early joint interactions with regulators and payers.•Conditional …

Patenting foundational technologies: Lessons from CRISPR and other core biotechnologies

O Feeney, J Cockbain, M Morrison… - The American Journal …, 2018 - Taylor & Francis
In 2012, a new and promising gene manipulation technique, CRISPR-Cas9, was
announced that seems likely to be a foundational technique in health care and agriculture …

Trends of CRISPR technology development and deployment into agricultural production-consumption systems

M Gupta, M Gerard, SS Padmaja, RK Sastry - World patent information, 2020 - Elsevier
Genome editing of food crops is emerging as a new tool to meet food and nutritional security
in the current scenario of disproportionate balances between rising population and …