Recent progress on the versatility of virus-like particles

C Qian, X Liu, Q Xu, Z Wang, J Chen, T Li, Q Zheng… - Vaccines, 2020 - mdpi.com
Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural
proteins of a virus in the absence of genetic material. Having similar morphology to natural …

Norovirus vaccines: current clinical development and challenges

M Tan - Pathogens, 2021 - mdpi.com
Noroviruses are the major viral pathogens causing epidemic and endemic acute
gastroenteritis with significant morbidity and mortality. While vaccines against norovirus …

Human noroviruses: recent advances in a 50-year history

RL Atmar, S Ramani, MK Estes - Current opinion in infectious …, 2018 - journals.lww.com
Norovirus epidemiology is complex and requires continued surveillance to track the
emergence of new strains and recombinants, especially with the continued progress in …

Norovirus vaccine: priorities for future research and development

S Esposito, N Principi - Frontiers in immunology, 2020 - frontiersin.org
Soon after its identification, norovirus (NoV) has been indicated as one of the most common
causes of outbreaks of acute gastroenteritis (AGE) and sporadic acute diarrhea episodes in …

Progress on norovirus vaccine research: public health considerations and future directions

CP Mattison, CV Cardemil, AJ Hall - Expert review of vaccines, 2018 - Taylor & Francis
Introduction: Noroviruses are the leading cause of foodborne illness worldwide, account for
approximately one-fifth of acute gastroenteritis (AGE) cases globally, and cause a …

Efficacy of an intramuscular bivalent norovirus GI. 1/GII. 4 virus-like particle vaccine candidate in healthy US adults

J Sherwood, PM Mendelman, E Lloyd, M Liu, J Boslego… - Vaccine, 2020 - Elsevier
Background We performed this first-in-human efficacy trial of Takeda's bivalent norovirus
vaccine candidate (TAK-214) against moderate or severe acute gastroenteritis (AGE) in …

Advances in human norovirus vaccine research

M Zhang, M Fu, Q Hu - Vaccines, 2021 - mdpi.com
Human norovirus (HuNoV) is the leading cause of acute gastroenteritis (AGE) worldwide,
which is highly stable and contagious, with a few virus particles being sufficient to establish …

Norovirus: facts and reflections from past, present, and future

Y Lucero, DO Matson, S Ashkenazi, S George… - Viruses, 2021 - mdpi.com
Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most
countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian …

[HTML][HTML] Sera antibody repertoire analyses reveal mechanisms of broad and pandemic strain neutralizing responses after human norovirus vaccination

LC Lindesmith, JR McDaniel, A Changela, R Verardi… - Immunity, 2019 - cell.com
Rapidly evolving RNA viruses, such as the GII. 4 strain of human norovirus (HuNoV), and
their vaccines elicit complex serological responses associated with previous exposure …

Human monoclonal antibodies that neutralize pandemic GII. 4 noroviruses

G Alvarado, K Ettayebi, RL Atmar, RG Bombardi… - Gastroenterology, 2018 - Elsevier
Background & Aims Human noroviruses are responsible for approximately 200,000 deaths
worldwide each year. In 2012, the GII. 4 Sydney strain emerged and became the major …