The human skeleton has remarkable regenerative properties, being one of the few
structures in the body that can heal by recreating its normal cellular composition, orientation …

While formation and regeneration of the skeleton have been studied for a long period of
time, significant scientific advances in this field continue to emerge based on an unmet …

Hypoxia inducible factors (HIFs) are oxygen dependent heterodimeric transcription factors
that mediate molecular responses to reductions in cellular oxygen (hypoxia). HIF signaling …

Background Traumatic brain injury (TBI) has been known to accelerate bone healing. Many
cells and molecules have been investigated but the exact mechanism is still unknown. The …

Bone defects are a common and challenging orthopedic problem with poor self-healing
ability and long treatment cycles. The difficult-to-heal bone defects cause a significant …

Infection is a common cause of impaired fracture healing. In the clinical setting, definitive
fracture treatment and infection are often treated separately and sequentially, by different …

There is an unmet need for improved, clinically relevant methods to longitudinally quantify
bone healing during fracture care. Here we develop a smart bone plate to wirelessly monitor …

Background: Open reduction and internal fixation (ORIF) has been widely performed
because the osteochondral component of the osteochondritis dissecans (OCD) lesion is the …

Background: Fracture healing is a very complex and well-orchestrated regenerative process
involving many cell types and molecular pathways. Despite the high efficiency of this …

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