Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

Colorectal tumors have been classified based on histologic factors, genetic factors, and
consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of …

Hypoxia-inducible transcription factors (HIFs) are fundamental to cellular adaptation to low
oxygen levels, but it is unclear how they interact with chromatin and activate their target …

Anemia is common in colorectal cancer (CRC) but its relationships with tumor
characteristics, systemic inflammation, and survival have not been well characterized. In this …

Standardization of tumor assessment lays the foundation for validation of grading systems,
permits reproducibility of oncologic studies among investigators, and increases confidence …

Recent studies have reported of an association between high serum apolipoprotein A1
(APOA1) levels and favorable prognosis in several malignancies, while the significance of …

Background While prophylactic human papillomavirus (HPV) vaccines will certainly reduce
the incidence of HPV-associated cancers, these malignancies remain a major health issue …

Background Cancer cachexia is a complex wasting syndrome affecting patients with
advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein …

Cell death can occur through numerous regulated mechanisms that are categorized by their
molecular machineries and differing effects on physiology. Apoptosis and necrosis, for …

Background Tumor necrosis (TN) correlates with adverse outcomes in numerous solid
tumors. However, its prognostic value in renal cell carcinoma (RCC) remains unclear. In this …