Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

Macrophages and conventional dendritic cells (cDCs) are distributed throughout the body,
maintaining tissue homeostasis and tolerance to self and orchestrating innate and adaptive …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Unlike the adaptive immune system, the innate immune system has classically been
characterized as being devoid of memory functions. However, recent research shows that …

In the past few years, our understanding of immunological memory has evolved remarkably
due to a growing body of new knowledge in innate immune memory and immunity …

Introduction Weight loss improves obesity-associated diabetes risk. However, most
individuals regain weight, which worsens the risk of developing diabetes and cardiovascular …

Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …