Schistosome egg migration: mechanisms, pathogenesis and host immune responses

AH Costain, AS MacDonald, HH Smits - Frontiers in immunology, 2018 - frontiersin.org
Many parasitic worms possess complex and intriguing life cycles, and schistosomes are no
exception. To exit the human body and progress to their successive snail host, Schistosoma …

Schistosome immunomodulators

S Acharya, AA Da'dara, PJ Skelly - PLoS Pathogens, 2021 - journals.plos.org
Schistosomes are long lived, intravascular parasitic platyhelminths that infect> 200 million
people globally. The molecular mechanisms used by these blood flukes to dampen host …

Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection

EL Houlder, KA Stam, JPR Koopman, MH König… - Science …, 2024 - science.org
Schistosomiasis is an infection caused by contact with Schistosoma-contaminated water and
affects more than 230 million people worldwide with varying morbidity. The roles of T helper …

Paediatric schistosomiasis: What we know and what we need to know

DNM Osakunor, MEJ Woolhouse… - PLoS neglected tropical …, 2018 - journals.plos.org
Schistosomiasis affects over 200 million people worldwide, most of whom are children.
Research and control strategies directed at preschool-aged children (PSAC), ie,≤ 5 years …

Th2 responses in schistosomiasis

K Fairfax, M Nascimento, SCC Huang, B Everts… - Seminars in …, 2012 - Springer
Schistosomiasis is caused by infection with parasitic flatworms of the genus Schistosoma. It
is characterized by the development of strong CD4+ T cell and B cell responses that, during …

Schistosomes in the lung: immunobiology and opportunity

EL Houlder, AH Costain, PC Cook… - Frontiers in …, 2021 - frontiersin.org
Schistosome infection is a major cause of global morbidity, particularly in sub-Saharan
Africa. However, there is no effective vaccine for this major neglected tropical disease, and …

Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis

P Masamba, AP Kappo - International journal of molecular sciences, 2021 - mdpi.com
The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …

Dynamics of host immune response development during Schistosoma mansoni infection

AH Costain, AT Phythian-Adams… - Frontiers in …, 2022 - frontiersin.org
Schistosomiasis is a disease of global significance, with severity and pathology directly
related to how the host responds to infection. The immunological narrative of …

Immunological mechanisms involved in macrophage activation and polarization in schistosomiasis

ICL Licá, GCCG Frazão, RA Nogueira, MGS Lira… - Parasitology, 2023 - cambridge.org
Human schistosomiasis is caused by helminths of the genus Schistosoma. Macrophages
play a crucial role in the immune regulation of this disease. These cells acquire different …

Behind enemy lines: immunomodulatory armamentarium of the schistosome parasite

JMM Angeles, VJP Mercado, PT Rivera - Frontiers in Immunology, 2020 - frontiersin.org
The deeply rooted, intricate relationship between the Schistosoma parasite and the human
host has enabled the parasite to successfully survive within the host and surreptitiously …