Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular
response that repairs the damage, degrades RNA polymerase II and shuts down global …