Bridging the regeneration gap: genetic insights from diverse animal models

AS Alvarado, PA Tsonis - Nature Reviews Genetics, 2006 - nature.com
Significant progress has recently been made in our understanding of animal regenerative
biology, spurred on by the use of a wider range of model organisms and an increasing …

Cellular, metabolic, and developmental dimensions of whole-body regeneration in Hydra

MC Vogg, W Buzgariu… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
Here we discuss the developmental and homeostatic conditions necessary for Hydra
regeneration. Hydra is characterized by populations of adult stem cells paused in the G2 …

Transgenesis in Hydra to characterize gene function and visualize cell behavior

A Klimovich, J Wittlieb, TCG Bosch - Nature protocols, 2019 - nature.com
The freshwater polyp Hydra is a cnidarian used as a model organism in a number of fields,
including the study of the origin and evolution of developmental mechanisms, aging …

[HTML][HTML] Insights into regeneration tool box: An animal model approach

AS Mehta, A Singh - Developmental biology, 2019 - Elsevier
For ages, regeneration has intrigued countless biologists, clinicians, and biomedical
engineers. In recent years, significant progress made in identification and characterization of …

Hydra, a powerful model for aging studies

S Tomczyk, K Fischer, S Austad… - Invertebrate reproduction …, 2015 - Taylor & Francis
Cnidarian Hydra polyps escape senescence, most likely due to the robust activity of their
three stem cell populations. These stem cells continuously self-renew in the body column …

[PDF][PDF] Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency

G Plickert, U Frank, WA Müller - International Journal of …, 2012 - researchgate.net
Hydractinia, a representative marine colonial hydroid, was the first organism in the history of
biology in which migratory precursors of germ cells were described and termed “stem …

Hydra Regeneration: Closing the Loop with Mechanical Processes in Morphogenesis

E Braun, K Keren - BioEssays, 2018 - Wiley Online Library
The convergence of morphogenesis into viable organisms under variable conditions
suggests closed‐loop dynamics involving multiscale functional feedback. We develop the …

Hydra, a niche for cell and developmental plasticity

B Galliot, M Miljkovic-Licina, R de Rosa… - Seminars in cell & …, 2006 - Elsevier
The silencing of genes whose expression is restricted to specific cell types and/or specific
regeneration stages opens avenues to decipher the molecular control of the cellular …

Programmed cell death in Hydra

A Böttger, O Alexandrova - Seminars in cancer biology, 2007 - Elsevier
Hydra is one of the simplest metazoans and thus an important model organism for studies
on the evolution of developmental mechanisms in multi-cellular animals. In Hydra apoptosis …

Hydra regeneration and epitheliopeptides

T Fujisawa - Developmental dynamics: an official publication of …, 2003 - Wiley Online Library
Hydra has been well known for over 200 years for its remarkable regenerative capacity. In
addition to small pieces excised from the body, reaggregates of dissociated single cells can …