From correlation to causation: analysis of metabolomics data using systems biology approaches

A Rosato, L Tenori, M Cascante, PR De Atauri Carulla… - Metabolomics, 2018 - Springer
Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data

J Xia, DS Wishart - Nucleic acids research, 2010 - academic.oup.com
Gene set enrichment analysis (GSEA) is a widely used technique in transcriptomic data
analysis that uses a database of predefined gene sets to rank lists of genes from microarray …

[HTML][HTML] METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression

D Yi, R Wang, X Shi, L Xu, Y Yilihamu… - Oncology …, 2020 - spandidos-publications.com
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer‑
related death among women worldwide. Evidence indicates that posttranscriptional N6 …

Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer

B Song, J Du, D Song, J Ren, Y Feng - Biological research, 2018 - SciELO Chile
SONG, Bin et al. Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-
1179 may contribute to the progression of gastric cancer. Biol. Res.[online]. 2018, vol. 51 …

[HTML][HTML] Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis

R Huang, W Gu, B Sun, L Gao - Molecular medicine …, 2018 - spandidos-publications.com
Trastuzumab, the first targeted antibody against human epidermal growth factor receptor 2
(HER2), has been used to treat gastric cancer patients with HER2 overexpression. However …

Identification of key candidate genes involved in melanoma metastasis

J Chen, F Wu, Y Shi, D Yang… - Molecular …, 2019 - spandidos-publications.com
Metastasis is the most lethal stage of cancer progression. The present study aimed to
investigate the underlying molecular mechanisms of melanoma metastasis using …

Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming

M Bekhbat, DR Goldsmith, BJ Woolwine… - Molecular …, 2021 - nature.com
Inflammation impacts basal ganglia motor circuitry in association with psychomotor
retardation, a key symptom of major depression (MD). We previously reported associations …

Identification of tRNA-derived fragments in colon cancer by comprehensive small RNA sequencing

W Xiong, X Wang, X Cai, W Xiong… - Oncology …, 2019 - spandidos-publications.com
Transfer RNA-derived fragments (tRFs) are a novel class of small non-coding RNAs that are
abundant in various species and have been implicated in human diseases. However, to the …

Identification of potential core genes in Parkinson's disease using bioinformatics analysis

W Quan, J Li, X Jin, L Liu, Q Zhang, Y Qin… - Parkinson's …, 2021 - Wiley Online Library
Purpose. This study aimed to explore new core genes related to the occurrence of
Parkinson's disease (PD) and core genes that can lead to the progression of PD. Methods …

Translation of genome-wide association study: from genomic signals to biological insights

WS Bruner, SFA Grant - Frontiers in Genetics, 2024 - frontiersin.org
Since the turn of the 21st century, genome-wide association study (GWAS) have
successfully identified genetic signals associated with a myriad of common complex traits …