Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

Abstract ADAR1‐mediated A‐to‐I RNA editing is a self‐/non‐self‐discrimination mechanism
for cellular double‐stranded RNAs. ADAR mutations are one cause of Aicardi–Goutières …

Early detection of infection is a central and critical component of our innate immune system.
Mammalian cells have developed specialized receptors that detect RNA with unusual …

Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme that catalyzes
adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals …

RNA modifications, also termed epitranscriptomic marks, encompass chemical alterations to
individual nucleotides, including processes such as methylation and editing. These marks …

Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …

Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands
as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in …

In this article, I recount my memories of key experiments that led to my entry into the RNA
editing/modification field. I highlight initial observations made by the pioneers in the ADAR …