Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …

The innate immune system is critical for inducing durable and protective T cell responses to
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Background Resistance to an immune checkpoint inhibitor (ICI) is a major obstacle in cancer
immunotherapy. The causes of ICI resistance include major histocompatibility complex …

Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have
been effective in only a small subset of patients and a principal mechanism underlying …

Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

Genomic and chromosomal instability are hallmarks of cancer and shape the genomic
composition of cancer cells, thereby determining their behavior and response to treatment …

Conclusions: This study reveals that persistent DNA damage caused by a defective BRCA
pathway induces tumor immunosuppression and T‐lymphocyte infiltration in HCC through …

Abstract Cyclic GMP-AMP synthase (cGAS) is an essential sensor of aberrant cytosolic DNA
for initiating innate immunity upon invading pathogens and cellular stress, which is …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …