Regeneration of pancreatic β-cells for diabetes therapeutics by natural DYRK1A inhibitors

Y Guo, L Li, Y Yao, H Li - Metabolites, 2022 - mdpi.com
The pathogenesis of diabetes mellitus is characterized by insulin resistance and islet β-cell
dysfunction. Up to now, the focus of diabetes treatment has been to control blood glucose to …

The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland

MC Iglesias-Osma, EJ Blanco… - Scientific reports, 2019 - nature.com
Involvement of IRS2 in the proliferative effects of IGF-I of follicular thyroid cells has been
described, but there are no evidences for in vivo participation of IRS2. This study aimed to …

The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina

MC Iglesias-Osma, EJ Blanco… - Annals of Anatomy …, 2022 - Elsevier
Insulin receptor substrate (Irs) belongs to a family of proteins that mediate the intracellular
signaling of insulin and IGF-1. Insulin receptor substrate 2 (Irs2) is necessary for retinal …

Protective effects of curcumin on the structure of the adrenal gland in diabetic rat model: A stereological, immunohistochemical and electron microscopic study …

G Altun, M Ulubay, EG Bakirhan… - Neuro-Cell …, 2024 - neurocellmolres.com.tr
This study investigated the ultrastructural changes in the adrenal gland in different stages of
diabetes (onset, early, late) and the protective effects of curcumin. Seven groups of Wistar …

[PDF][PDF] Novel approaches for diabetes management by inhibition of DYRK1A kinase

A Barzowska - 2024 - ruj.uj.edu.pl
Diabetes mellitus is a group of metabolic conditions characterized by elevated blood
glucose levels resulting from problems with insulin secretion, insulin action, or both …