HIV and HLA class I: an evolving relationship
PJR Goulder, BD Walker - Immunity, 2012 - cell.com
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
Programming cytomegalovirus as an HIV vaccine
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
Unravelling the mechanisms of durable control of HIV-1
Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
Vaccine-induced CD8+ T cells control AIDS virus replication
Developing a vaccine for human immunodeficiency virus (HIV) may be aided by a complete
understanding of those rare cases in which some HIV-infected individuals control replication …
understanding of those rare cases in which some HIV-infected individuals control replication …
Elucidating the elite: mechanisms of control in HIV-1 infection
KA O'Connell, JR Bailey, JN Blankson - Trends in pharmacological …, 2009 - cell.com
In patients with progressive disease, untreated HIV-1 infection is characterized by high viral
loads and decreasing CD4+ T cell counts which lead to opportunistic infection and other …
loads and decreasing CD4+ T cell counts which lead to opportunistic infection and other …
ALT-803 transiently reduces simian immunodeficiency virus replication in the absence of antiretroviral treatment
AL Ellis-Connell, AJ Balgeman, KR Zarbock… - Journal of …, 2018 - Am Soc Microbiol
Developing biological interventions to control human immunodeficiency virus (HIV)
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
MHC heterozygote advantage in simian immunodeficiency virus–infected Mauritian cynomolgus macaques
SL O'Connor, JJ Lhost, EA Becker… - Science translational …, 2010 - science.org
The importance of a broad CD8 T lymphocyte (CD8-TL) immune response to HIV is
unknown. Ex vivo measurements of immunological activity directed at a limited number of …
unknown. Ex vivo measurements of immunological activity directed at a limited number of …
MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection
AL Ellis, AJ Balgeman, EC Larson, MA Rodgers… - PLoS …, 2020 - journals.plos.org
Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially
infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) …
infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) …
Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species
NG de Groot, N Otting, J Robinson, A Blancher… - Immunogenetics, 2012 - Springer
The major histocompatibility complex (MHC) plays a central role in the adaptive immune
response. The MHC region is characterised by a high gene density, and most of these …
response. The MHC region is characterised by a high gene density, and most of these …
Role of HLA adaptation in HIV evolution
Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus
toward escape. The HLA class I molecules that are successful in mediating some degree of …
toward escape. The HLA class I molecules that are successful in mediating some degree of …