After the emergence of a novel coronavirus named SARS‐CoV‐2, coronavirus disease 2019
(COVID‐19) was initially characterized by fever, sore throat, cough, and dyspnea, mainly …

Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

Objective: To determine the efficacy of an angiotensin converting enzyme inhibitor in the
prophylaxis of migraine. Design: Double blind, placebo controlled, crossover study. Setting …

Epidemiological studies suggests that migraine is associated with disorders of the cerebral,
coronary, retinal, dermal and peripheral vasculature. There is evidence that migraine is …

Although family and twin studies show that there is a genetic component to migraine, no
genes predisposing to common forms of the disorder have been identified. The most …

(Headache 2011; 51: 752‐778) Pain research, and headache research in particular, during
the 20th century, has generated an enormous volume of literature promulgating theories …

Several cellular and molecular mechanisms have been implicated in migraine
pathophysiology including abnormal neuronal excitability and vascular events. Drugs from …

Objective The focus of this review is to review potential diagnostic and therapeutic
biomarkers associated with migraine. Background Migraine headache is a common disease …

Substance P (SP), calcitonin gene-related peptide (CGRP), and angiotensin converting
enzyme (ACE) may have roles in trigeminovascular nociceptive mechanisms. We …