The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention

S Domínguez-Zorita, JM Cuezva - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a global health problem with high personal and economic
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

The ATPase Inhibitory Factor 1 (IF1) Contributes to the Warburg Effect and Is Regulated by Its Phosphorylation in S39 by a Protein Kinase A-like Activity

JM Cuezva, S Domínguez-Zorita - Cancers, 2024 - mdpi.com
Simple Summary The ATPase Inhibitory Factor 1 (IF1) plays a prominent role as an inhibitor
of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg …

[HTML][HTML] Exacerbated response to oxidative stress in the Retinitis Pigmentosa CerklKD/KO mouse model triggers retinal degeneration pathways upon acute light stress

R García-Arroyo, EB Domènech, C Herrera-Úbeda… - Redox Biology, 2023 - Elsevier
The retina is particularly vulnerable to genetic and environmental alterations that generate
oxidative stress and cause cellular damage in photoreceptors and other retinal neurons …

[HTML][HTML] Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression

MS Savova, MN Todorova, AG Apostolov… - Biomedicine & …, 2022 - Elsevier
Obesity is an ingrained health problem with а multifactorial origin and а long history, thereby
innovations in the treatment strategies are of great importance. In the search of a remedy for …

Genetics of enzymatic dysfunctions in metabolic disorders and cancer

M Mahé, TJ Rios-Fuller, A Karolin… - Frontiers in …, 2023 - frontiersin.org
Inherited metabolic disorders arise from mutations in genes involved in the biogenesis,
assembly, or activity of metabolic enzymes, leading to enzymatic deficiency and severe …

[HTML][HTML] Novel Spatial Approaches to Dissect the Lung Cancer Immune Microenvironment

I Lubo, S Hernandez, II Wistuba, LM Solis Soto - Cancers, 2024 - mdpi.com
Lung cancer is a deadly disease with the highest rates of mortality. Over recent decades, a
better understanding of the biological mechanisms implicated in its pathogenesis has led to …

Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival

I Romero-Carramiñana, S Dominguez-Zorita… - Iscience, 2024 - cell.com
T cells experience metabolic reprogramming to an enhanced glycolysis upon activation.
Herein, we have investigated whether ATPase Inhibitory Factor 1 (IF1), the physiological …

Multi-omics Research on the Heterogeneity and Immune Landscape of Lung Adenocarcinoma with Ground-glass opacity

H Miao, X Teng, X Teng, S Fu, M Gao, H Xu - 2022 - researchsquare.com
Background: Lung adenocarcinoma with ground-glass opacity (GGO) has been detected
increasingly and now accounts for most lung cancer patients. Lung adenocarcinoma with …

[引用][C] Metabolismo mitocondrial: terapias que suponen el futuro del tratamiento del cáncer

CG Callejas, MA Torres, YA Castro - Revista Estudiantil HolCien, 2023