The microtubule cytoskeleton: An old validated target for novel therapeutic drugs

L Lafanechère - Frontiers in Pharmacology, 2022 - frontiersin.org
Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: the CNTRICS initiative

MJ Millan, KL Bales - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Social cognition refers to processes used to monitor and interpret social signals from others,
to decipher their state of mind, emotional status and intentions, and select appropriate social …

Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice

A Ortega-Alvaro, A Aracil-Fernández… - …, 2011 - nature.com
The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Neuromolecular basis of parental behavior in laboratory mice and rats: with special emphasis on technical issues of using mouse genetics

KO Kuroda, K Tachikawa, S Yoshida… - Progress in Neuro …, 2011 - Elsevier
To support the well-being of the parent–infant relationship, the neuromolecular mechanisms
of parental behaviors should be clarified. From neuroanatomical analyses in laboratory rats …

The microtubule cytoskeleton at the synapse

J Parato, F Bartolini - Neuroscience letters, 2021 - Elsevier
In neurons, microtubules (MTs) provide routes for transport throughout the cell and structural
support for dendrites and axons. Both stable and dynamic MTs are necessary for normal …

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia

A Merenlender-Wagner, Z Shemer, O Touloumi… - Autophagy, 2014 - Taylor & Francis
Autophagy plays a key role in the pathophysiology of schizophrenia as manifested by a 40%
decrease in BECN1/Beclin 1 mRNA in postmortem hippocampal tissues relative to controls …

Beyond neuronal microtubule stabilization: MAP6 and CRMPS, two converging stories

C Cuveillier, B Boulan, C Ravanello… - Frontiers in Molecular …, 2021 - frontiersin.org
The development and function of the central nervous system rely on the microtubule (MT)
and actin cytoskeletons and their respective effectors. Although the structural role of the …

Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice

IH Jung, HE Lee, SJ Park, YJ Ahn, G Kwon… - Pharmacology …, 2014 - Elsevier
Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa.
This study investigated the effect of spinosin on cholinergic blockade-induced memory …

Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth

JC Deloulme, S Gory-Fauré, F Mauconduit… - Nature …, 2015 - nature.com
Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that
was thought to be essential for development, maintenance and function of neuronal circuits …

Neuroprotective effect of quercetin against rotenone‐induced neuroinflammation and alterations in mice behavior

J Jain, W Hasan, P Biswas… - Journal of Biochemical …, 2022 - Wiley Online Library
Various studies suggested that neuroinflammation leads to the development of several
neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and …