Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2022 - mdpi.com
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the
biochemical processes leading to elevated production of reactive oxygen species (ROS) …

Health effects of quercetin: from antioxidant to nutraceutical

AW Boots, GRMM Haenen, A Bast - European journal of pharmacology, 2008 - Elsevier
Quercetin, a member of the flavonoids family, is one of the most prominent dietary
antioxidants. It is ubiquitously present in foods including vegetables, fruit, tea and wine as …

In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina

MN Wickramaratne, JC Punchihewa… - … and alternative medicine, 2016 - Springer
Background Diabetes has caused a major burden to the health sector in the developing
countries and has shown an increasing trend among the urban population. It is estimated …

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

F Ng, M Berk, O Dean, AI Bush - International Journal of …, 2008 - academic.oup.com
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may
be a common pathogenic mechanism underlying many major psychiatric disorders, as the …

Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis

H Kaneto, N Katakami, M Matsuhisa… - Mediators of …, 2010 - Wiley Online Library
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and
its hallmarks are pancreatic β‐cell dysfunction and insulin resistance. Under diabetic …

Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components

SG Martins, R Zilhão, S Thorsteinsdóttir… - Frontiers in …, 2021 - frontiersin.org
Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

CM Kusminski, WL Holland, K Sun, J Park… - Nature medicine, 2012 - nature.com
We examined mouse models with altered adipocyte expression of mitoNEET, a protein
residing in the mitochondrial outer membrane, to probe its impact on mitochondrial function …

Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review

J Wu, S Shi, H Wang, S Wang - Carbohydrate polymers, 2016 - Elsevier
Type 2 diabetes mellitus, a common metabolic and endocrine disorder worldwide, causes
severe health and economic problems. At present, pharmacotherapy involving synthetic …

The role of reactive oxygen species (ROS) in the formation of extracellular traps (ETs) in humans

W Stoiber, A Obermayer, P Steinbacher… - Biomolecules, 2015 - mdpi.com
Extracellular traps (ETs) are reticulate structures of extracellular DNA associated with
antimicrobial molecules. Their formation by phagocytes (mainly by neutrophils: NETs) has …

The central role of glutathione in the pathophysiology of human diseases

R Franco, OJ Schoneveld, A Pappa… - Archives of physiology …, 2007 - Taylor & Francis
Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …