Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …
context of the role that the lipid membrane can play in drug action, ie, the interaction …
Toward manipulating serotonin signaling via the microbiota–gut–brain axis
Highlights•Serotonin can interact with bacterial proteins with a range of effects.•Serotonin is
used in signaling between members of the microbiome and host.•Microbiome dysbiosis is …
used in signaling between members of the microbiome and host.•Microbiome dysbiosis is …
Phospholipid membranes as chemically and functionally tunable materials
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …
Atomic force microscopy and other scanning probe microscopy methods to study nanoscale domains in model lipid membranes
M Robinson, CT Filice, DM McRae… - Advances in Physics …, 2023 - Taylor & Francis
The cell membrane is a fundamental biological structure, which is only 6–10 nm thick. It is
composed of hundreds of lipid types, which form small and dynamic lipid domains or rafts …
composed of hundreds of lipid types, which form small and dynamic lipid domains or rafts …
Serotonergic drugs modulate the phase behavior of complex lipid bilayers
Serotonin is an endogenous neurotransmitter involved in both physiological and
pathophysiological processes. Traditionally, serotonin acts as a ligand for G protein-coupled …
pathophysiological processes. Traditionally, serotonin acts as a ligand for G protein-coupled …
Membrane-Mediated Allosteric Action of Serotonin on a Noncognate G-Protein-Coupled Receptor
The structure and dynamics of the lipid membrane can affect the activity of membrane
proteins. Therefore, small lipophilic molecules that alter membrane properties (such as the …
proteins. Therefore, small lipophilic molecules that alter membrane properties (such as the …
Selective advantages of synapses in evolution
LL Moroz, DY Romanova - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
The common ancestor of all Metazoa (Urmetazoan) was a nerveless animal (Mackie, 1970,
1990; Moroz, 2009). This hypothetical Urmetazoan likely used electrical and chemical …
1990; Moroz, 2009). This hypothetical Urmetazoan likely used electrical and chemical …
Unusual Robustness of Neurotransmitter Vesicle Membranes against Serotonin-Induced Perturbations
Nature confines hundreds of millimolar of amphiphilic neurotransmitters, such as serotonin,
in synaptic vesicles. This appears to be a puzzle, as the mechanical properties of lipid …
in synaptic vesicles. This appears to be a puzzle, as the mechanical properties of lipid …
Different membrane order measurement techniques are not mutually consistent
Abstract" Membrane order" is a term commonly used to describe the elastic and mechanical
properties of the lipid bilayer, though its exact meaning is somewhat context-and method …
properties of the lipid bilayer, though its exact meaning is somewhat context-and method …
Structural details on the interaction of fenamates with lipid membranes
IA Khodov, GS Musabirova, VV Klochkov… - Journal of Molecular …, 2022 - Elsevier
Fenamates are nonsteroidal anti-inflammatory drugs (NSAID), usually prescribed to treat
pain and inflammation and, like other NSAIDs, to inhibit cyclooxygenases. They have also …
pain and inflammation and, like other NSAIDs, to inhibit cyclooxygenases. They have also …