Prion disease is a rare, fatal, and exceptionally rapid neurodegenerative disease. Although
incurable, prion disease follows a clear pathogenic mechanism, in which a single gene …

Prion diseases are a group of incurable zoonotic neurodegenerative diseases (NDDs) in
humans and other animals caused by the prion proteins. The abnormal folding and …

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO) …

Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …

Prion disease is a fatal, incurable neurodegenerative disease of humans and other
mammals caused by conversion of cellular prion protein (PrP C) into a self-propagating …

Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt–
Jakob disease (CJD). The absence of a human cell culture model that replicates human …

Objective To determine whether preventive trials in genetic prion disease could be designed
to follow presymptomatic mutation carriers to onset of disease. Methods We assembled age …

Prions, which cause fatal neurodegenerative disorders such as Creutzfeldt‐Jakob disease,
are misfolded and infectious protein aggregates. Currently, there are no treatments available …

Phenotypic screening has yielded small-molecule inhibitors of prion replication that are
effective in vivo against certain prion strains but not others. Here, we sought to test the small …

Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including Sapiens. Prions are composed of PrPSc, the …