ATRX, a guardian of chromatin

P Aguilera, AJ López-Contreras - Trends in Genetics, 2023 - cell.com
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

DAXX in cancer: phenomena, processes, mechanisms and regulation

I Mahmud, D Liao - Nucleic acids research, 2019 - academic.oup.com
DAXX displays complex biological functions. Remarkably, DAXX overexpression is a
common feature in diverse cancers, which correlates with tumorigenesis, disease …

ProteinsPlatform constructed from biofuctionalized-magnetized nano-chitosan for efficient separation of multi-tagged fusion proteins

M Gao, C Xu, J Deng, T Zhu, Z Xie, X Zou… - Chemical Engineering …, 2024 - Elsevier
Chitosan (CS) was deposited onto the surface of Fe 3 O 4 nanoparticles by anionic cross-
linking to obtain Fe 3 O 4@ CS nanocomposite with improved biocompatibility ascribed to …

[HTML][HTML] Almost famous: Human adenoviruses (and what they have taught us about cancer)

TM Tessier, MJ Dodge, KM MacNeil, AM Evans… - Tumour Virus …, 2021 - Elsevier
Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the
small DNA tumour viruses. Notably, human adenoviruses were the first human viruses …

Identification of ASF1A and HJURP by global H3–H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma

Y Liu, S Liu, R Jing, C Li, Y Guo, Z Cai, P Xi, P Dai… - Scientific Reports, 2024 - nature.com
Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis. Abnormal expression
of H3–H4 histone chaperones has been identified in many cancers and holds promise as a …

Well-differentiated G1 and G2 pancreatic neuroendocrine tumors: a meta-analysis of published expanded DNA sequencing data

KØ Andersen, S Detlefsen, K Brusgaard… - Frontiers in …, 2024 - frontiersin.org
Introduction Well-differentiated pancreatic neuroendocrine tumors (PNETs) can be non-
functional or functional, eg insulinoma and glucagonoma. The majority of PNETs are …

Phosphorylation of 'SDT-like'motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression

T Goncalves, H Bhatnagar, S Cunniffe… - Open …, 2024 - royalsocietypublishing.org
Approximately 10–15% of human cancers are telomerase-negative and maintain their
telomeres through a recombination-based process known as the alternative lengthening of …

Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor

R Quevedo, A Spreafico, J Bruce, A Danesh… - Genome Medicine, 2020 - Springer
Abstract Background Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing
cancers that often present with local and distant metastasis upon detection. PANETS contain …

Dynamic Activity of histone H3-specific chaperone complexes in oncogenesis

T Wen, QY Chen - Frontiers in Oncology, 2022 - frontiersin.org
Canonical histone H3. 1 and variant H3. 3 deposit at different sites of the chromatin via
distinct histone chaperones. Histone H3. 1 relies on chaperone CAF-1 to mediate replication …

DAXX is a crucial factor for proper development of mammalian oocytes and early embryos

I Bogolyubova, D Bogolyubov - International Journal of Molecular …, 2021 - mdpi.com
The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and
ubiquitously expressed multifunctional protein that is implicated in many cellular processes …