Translational opportunities and challenges of invasive electrodes for neural interfaces
Invasive brain–machine interfaces can restore motor, sensory and cognitive functions.
However, their clinical adoption has been hindered by the surgical risk of implantation and …
However, their clinical adoption has been hindered by the surgical risk of implantation and …
Neuronal circuits in barrel cortex for whisker sensory perception
JF Staiger, CCH Petersen - Physiological reviews, 2021 - journals.physiology.org
The array of whiskers on the snout provides rodents with tactile sensory information relating
to the size, shape and texture of objects in their immediate environment. Rodents can use …
to the size, shape and texture of objects in their immediate environment. Rodents can use …
Local connectivity and synaptic dynamics in mouse and human neocortex
L Campagnola, SC Seeman, T Chartrand, L Kim… - Science, 2022 - science.org
We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …
dataset. Through its application, we reveal principles that relate cell type to synaptic …
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
The superior colliculus is a midbrain structure that plays important roles in visually guided
behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal …
behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal …
Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus
Abstract Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits
are thought to play a key role in several higher network functions, such as feedforward and …
are thought to play a key role in several higher network functions, such as feedforward and …
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
SC Seeman, L Campagnola, PA Davoudian… - elife, 2018 - elifesciences.org
Generating a comprehensive description of cortical networks requires a large-scale,
systematic approach. To that end, we have begun a pipeline project using multipatch …
systematic approach. To that end, we have begun a pipeline project using multipatch …
[HTML][HTML] Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice
The medial prefrontal cortex (mPFC) mediates a variety of complex cognitive functions via its
vast and diverse connections with cortical and subcortical structures. Understanding the …
vast and diverse connections with cortical and subcortical structures. Understanding the …
Active dendrites enable strong but sparse inputs to determine orientation selectivity
The dendrites of neocortical pyramidal neurons are excitable. However, it is unknown how
synaptic inputs engage nonlinear dendritic mechanisms during sensory processing in vivo …
synaptic inputs engage nonlinear dendritic mechanisms during sensory processing in vivo …
Rapid sensory adaptation redux: a circuit perspective
CJ Whitmire, GB Stanley - Neuron, 2016 - cell.com
Adaptation is fundamental to life. All organisms adapt over timescales that span from
evolution to generations and lifetimes to moment-by-moment interactions. The nervous …
evolution to generations and lifetimes to moment-by-moment interactions. The nervous …
Excitatory and inhibitory subnetworks are equally selective during decision-making and emerge simultaneously during learning
Inhibitory neurons, which play a critical role in decision-making models, are often simplified
as a single pool of non-selective neurons lacking connection specificity. This assumption is …
as a single pool of non-selective neurons lacking connection specificity. This assumption is …