Predicting archaic hominin phenotypes from genomic data
Ancient DNA provides a powerful window into the biology of extant and extinct species,
including humans' closest relatives: Denisovans and Neanderthals. Here, we review what is …
including humans' closest relatives: Denisovans and Neanderthals. Here, we review what is …
Genetic disease risks can be misestimated across global populations
Background Accurate assessment of health disparities requires unbiased knowledge of
genetic risks in different populations. Unfortunately, most genome-wide association studies …
genetic risks in different populations. Unfortunately, most genome-wide association studies …
Population differentiation of polygenic score predictions under stabilizing selection
Given the many small-effect loci uncovered by genome-wide association studies (GWAS),
polygenic scores have become central to genomic medicine, and have found application in …
polygenic scores have become central to genomic medicine, and have found application in …
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers
Human culture, biology, and health were shaped dramatically by the onset of agriculture∼
12,000 y BP This shift is hypothesized to have resulted in increased individual fitness and …
12,000 y BP This shift is hypothesized to have resulted in increased individual fitness and …
Skeletal anomalies in the Neandertal family of El Sidrón (Spain) support a role of inbreeding in Neandertal extinction
Neandertals disappeared from the fossil record around 40,000 bp, after a demographic
history of small and isolated groups with high but variable levels of inbreeding, and …
history of small and isolated groups with high but variable levels of inbreeding, and …
The utility of genomic prediction models in evolutionary genetics
SE McGaugh, AJ Lorenz… - Proceedings of the …, 2021 - royalsocietypublishing.org
Variation in complex traits is the result of contributions from many loci of small effect. Based
on this principle, genomic prediction methods are used to make predictions of breeding …
on this principle, genomic prediction methods are used to make predictions of breeding …
[HTML][HTML] Genome of Peştera Muierii skull shows high diversity and low mutational load in pre-glacial Europe
E Svensson, T Günther, A Hoischen, M Hervella… - Current Biology, 2021 - cell.com
Few complete human genomes from the European Early Upper Palaeolithic (EUP) have
been sequenced. Using novel sampling and DNA extraction approaches, we sequenced the …
been sequenced. Using novel sampling and DNA extraction approaches, we sequenced the …
Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples
P Esteller-Cucala, I Maceda, AD Børglum… - Scientific Reports, 2020 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is an impairing neurodevelopmental
condition highly prevalent in current populations. Several hypotheses have been proposed …
condition highly prevalent in current populations. Several hypotheses have been proposed …
[HTML][HTML] Ancestral genomic contributions to complex traits in contemporary Europeans
The contemporary European genetic makeup formed in the last 8,000 years when local
Western Hunter-Gatherers (WHGs) mixed with incoming Anatolian Neolithic farmers and …
Western Hunter-Gatherers (WHGs) mixed with incoming Anatolian Neolithic farmers and …
A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa
M Harlemon, O Ajayi, P Kachambwa, MS Kim… - Cancer research, 2020 - AACR
Although prostate cancer is the leading cause of cancer mortality for African men, the vast
majority of known disease associations have been detected in European study cohorts …
majority of known disease associations have been detected in European study cohorts …